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A trade route spanning most of the eastern half of Middle Earth it goes through the following places:

Khazad Sarkhah

Dale

Kheled-Arnin (Main trading center for Mithril)

Minas Tirith

Astarus

It's used by hundreds of merchants to get very foreign goods to places where it is next to unexistant, making much of the produce and goods on the route very expensive but also very perplexing.